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Structure paper

TitleStructure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1.
Journal, issue, pagesNat. Chem. Biol., Vol. 5, Page 758-764, Year 2009
Publish dateJun 9, 2009 (structure data deposition date)
AuthorsHindie, V. / Stroba, A. / Zhang, H. / Lopez-Garcia, L.A. / Idrissova, L. / Zeuzem, S. / Hirschberg, D. / Schaeffer, F. / Jrgensen, T.J. / Engel, M. ...Hindie, V. / Stroba, A. / Zhang, H. / Lopez-Garcia, L.A. / Idrissova, L. / Zeuzem, S. / Hirschberg, D. / Schaeffer, F. / Jrgensen, T.J. / Engel, M. / Alzari, P.M. / Biondi, R.M.
External linksNat. Chem. Biol. / PubMed:19718043
MethodsX-ray diffraction
Resolution1.9 - 1.91 Å
Structure data

PDB-3hrc:
Crystal structure of a mutant of human PDK1 Kinase domain in complex with ATP
Method: X-RAY DIFFRACTION / Resolution: 1.91 Å

PDB-3hrf:
Crystal structure of Human PDK1 kinase domain in complex with an allosteric activator bound to the PIF-pocket
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM

ChemComp-HOH:
WATER

ChemComp-P47:
(2Z)-5-(4-chlorophenyl)-3-phenylpent-2-enoic acid

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / AGC Kinase / PHOSPHORYLATION / ALLOSTERY / PDK1 / ACTIVATION LOOP / ATP BINDING / ATP-binding / Kinase / Membrane / Nucleotide-binding / Phosphoprotein / Serine/threonine-protein kinase / PIF-POCKET / ALPHA-C HELIX

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