| タイトル | Structural evaluation of potent NKT cell agonists: implications for design of novel stimulatory ligands. |
|---|
| ジャーナル・号・ページ | J. Mol. Biol., Vol. 394, Page 71-82, Year 2009 |
|---|
| 掲載日 | 2009年3月14日 (構造データの登録日) |
|---|
著者 | Schiefner, A. / Fujio, M. / Wu, D. / Wong, C.H. / Wilson, I.A. |
|---|
リンク | J. Mol. Biol. / PubMed:19732779 |
|---|
| 手法 | X線回折 |
|---|
| 解像度 | 1.6 - 1.9 Å |
|---|
| 構造データ | PDB-3gml: Structure of mouse CD1d in complex with C6Ph 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-3gmm: Structure of mouse CD1d in complex with C8Ph 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-3gmn: Structure of mouse CD1d in complex with C10Ph 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-3gmo: Structure of mouse CD1d in complex with C8PhF 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-3gmp: Structure of mouse CD1d in complex with PBS-25 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-3gmq: Structure of mouse CD1d expressed in SF9 cells, no ligand added 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-3gmr: Structure of mouse CD1d in complex with C8Ph, different space group 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å |
|---|
| 化合物 | ChemComp-NAG: 2-acetamido-2-deoxy-beta-D-glucopyranose
ChemComp-C6Q: N-{(1S,2S,3R)-1-[(alpha-D-galactopyranosyloxy)methyl]-2,3-dihydroxyheptadecyl}-6-phenylhexanamide
ChemComp-C8P: N-{(1S,2S,3R)-1-[(alpha-D-galactopyranosyloxy)methyl]-2,3-dihydroxyheptadecyl}-8-phenyloctanamide
ChemComp-C1Q: N-{(1S,2S,3R)-1-[(alpha-D-galactopyranosyloxy)methyl]-2,3-dihydroxyheptadecyl}-10-phenyldecanamide
ChemComp-C8F: 8-(4-fluorophenyl)-N-{(1S,2S,3R)-1-[(alpha-D-galactopyranosyloxy)methyl]-2,3-dihydroxyheptadecyl}octanamide
ChemComp-PBS: (2S,3S,4R)-N-OCTANOYL-1-[(ALPHA-D-GALACTOPYRANOSYL)OXY]-2-AMINO-OCTADECANE-3,4-DIOL
|
|---|
| 由来 |  mus musculus (ハツカネズミ)
|
|---|
キーワード | IMMUNE SYSTEM / CD1 / NKT cell / glycolipid / antigen presentation / Cell membrane / Disulfide bond / Endosome / Glycoprotein / Immune response / Immunoglobulin domain / Innate immunity / Lysosome / Membrane / Transmembrane / MHC I / Secreted |
|---|