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Structure paper

TitleDissecting specificity in the Janus kinases: the structures of JAK-specific inhibitors complexed to the JAK1 and JAK2 protein tyrosine kinase domains.
Journal, issue, pagesJ. Mol. Biol., Vol. 387, Page 219-232, Year 2009
Publish dateOct 20, 2008 (structure data deposition date)
AuthorsWilliams, N.K. / Bamert, R.S. / Patel, O. / Wang, C. / Walden, P.M. / Wilks, A.F. / Fantino, E. / Rossjohn, J. / Lucet, I.S.
External linksJ. Mol. Biol. / PubMed:19361440
MethodsX-ray diffraction
Resolution1.9 - 2.4 Å
Structure data

PDB-3eyg:
Crystal structures of JAK1 and JAK2 inhibitor complexes
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-3eyh:
Crystal structures of JAK1 and JAK2 inhibitor complexes
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-3fup:
Crystal structures of JAK1 and JAK2 inhibitor complexes
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-MI1:
3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile / medication, inhibitor*YM

ChemComp-HOH:
WATER

ChemComp-IZA:
2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / JAK kinase / ATP-binding / Kinase / Nucleotide-binding / Phosphoprotein / SH2 domain / Tyrosine-protein kinase / PTK domain / Protein-inhibitor complex / Chromosomal rearrangement / Disease mutation / Membrane / Polymorphism / Proto-oncogene

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