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-Structure paper
Title | Slow binding inhibition and mechanism of resistance of non-nucleoside polymerase inhibitors of hepatitis C virus. |
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Journal, issue, pages | J. Biol. Chem., Vol. 284, Page 15517-15529, Year 2009 |
Publish date | Jan 7, 2009 (structure data deposition date) |
![]() | Hang, J.Q. / Yang, Y. / Harris, S.F. / Leveque, V. / Whittington, H.J. / Rajyaguru, S. / Ao-Ieong, G. / McCown, M.F. / Wong, A. / Giannetti, A.M. ...Hang, J.Q. / Yang, Y. / Harris, S.F. / Leveque, V. / Whittington, H.J. / Rajyaguru, S. / Ao-Ieong, G. / McCown, M.F. / Wong, A. / Giannetti, A.M. / Le Pogam, S. / Talamas, F. / Cammack, N. / Najera, I. / Klumpp, K. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 1.8 - 2.2 Å |
Structure data | ![]() PDB-3fqk: ![]() PDB-3fql: |
Chemicals | ![]() ChemComp-79Z: ![]() ChemComp-HOH: ![]() ChemComp-GOL: |
Source |
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![]() | TRANSFERASE / HCV / HEPATITIS / NS5B / RNA-DEPENDENT RNA POLYMERASE / HCV-796 |