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-Structure paper
Title | Correlations of Inhibitor Kinetics for Pneumocystis jirovecii and Human Dihydrofolate Reductase with Structural Data for Human Active Site Mutant Enzyme Complexes. |
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Journal, issue, pages | Biochemistry, Vol. 48, Page 1702-1711, Year 2009 |
Publish date | Nov 13, 2008 (structure data deposition date) |
Authors | Cody, V. / Pace, J. / Makin, J. / Piraino, J. / Queener, S.F. / Rosowsky, A. |
External links | Biochemistry / PubMed:19196009 |
Methods | X-ray diffraction |
Resolution | 1.23 - 2.01 Å |
Structure data | PDB-3f8y: PDB-3f8z: PDB-3f91: PDB-3fs6: |
Chemicals | ChemComp-DH1: ChemComp-NDP: ChemComp-SO4: ChemComp-HOH: |
Source |
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Keywords | OXIDOREDUCTASE / active site mutants ligand complex DHFR / NADP / One-carbon metabolism / active site mutants ligand complex human dihydrofolate reductase / human wild type DHFR active site inhibitors |