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Title | Discovery of N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a Selective and Orally Efficacious Inhibitor of the Met Kinase Superfamily |
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Journal, issue, pages | J. Med. Chem., Vol. 52, Page 1251-1254, Year 2009 |
Publish date | Nov 11, 2008 (structure data deposition date) |
Authors | Schroeder, G.M. / An, Y. / Cai, Z.W. / Chen, X.T. / Clark, C. / Cornelius, L.A. / Dai, J. / Gullo-Brown, J. / Gupta, A. / Henley, B. ...Schroeder, G.M. / An, Y. / Cai, Z.W. / Chen, X.T. / Clark, C. / Cornelius, L.A. / Dai, J. / Gullo-Brown, J. / Gupta, A. / Henley, B. / Hunt, J.T. / Jeyaseelan, R. / Kamath, A. / Kim, K. / Lippy, J. / Lombardo, L.J. / Manne, V. / Oppenheimer, S. / Sack, J.S. / Schmidt, R.J. / Shen, G. / Stefanski, K. / Tokarski, J.S. / Trainor, G.L. / Wautlet, B.S. / Wei, D. / Williams, D.K. / Zhang, Y. / Fargnoli, J. / Borzilleri, R.M. |
External links | J. Med. Chem. / PubMed:19260711 |
Methods | X-ray diffraction |
Resolution | 2.5 Å |
Structure data | PDB-3f82: |
Chemicals | ChemComp-353: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE / Alternative splicing / RECEPTOR TYROSINE KINASE / SIGNAL TRANSDUCTION / GRB2 / SHC / ATP-BINDING / GLYCOPROTEIN / MEMBRANE / NUCLEOTIDE-BINDING / PHOSPHOPROTEIN / PROTO-ONCOGENE / TRANSMEMBRANE / TYROSINE-PROTEIN KINASE |