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TitleDiscovery of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines: Potent inhibitors of the IGF-1R receptor tyrosine kinase.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 19, Page 469-473, Year 2009
Publish dateSep 19, 2008 (structure data deposition date)
AuthorsChamberlain, S.D. / Wilson, J.W. / Deanda, F. / Patnaik, S. / Redman, A.M. / Yang, B. / Shewchuk, L. / Sabbatini, P. / Leesnitzer, M.A. / Groy, A. ...Chamberlain, S.D. / Wilson, J.W. / Deanda, F. / Patnaik, S. / Redman, A.M. / Yang, B. / Shewchuk, L. / Sabbatini, P. / Leesnitzer, M.A. / Groy, A. / Atkins, C. / Gerding, R. / Hassell, A.M. / Lei, H. / Mook, R.A. / Moorthy, G. / Rowand, J.L. / Stevens, K.L. / Kumar, R. / Shotwell, J.B.
External linksBioorg. Med. Chem. Lett. / PubMed:19056263
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-3ekk:
Insulin receptor kinase complexed with an inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-GS2:
2-[(2-{[1-(N,N-dimethylglycyl)-5-methoxy-1H-indol-6-yl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-6-fluoro-N-methylbenzamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / insulin / tyrosine kinase / ATP-binding / Carbohydrate metabolism / Cleavage on pair of basic residues / Diabetes mellitus / Disease mutation / Glycoprotein / Kinase / Membrane / Nucleotide-binding / Phosphoprotein / Receptor / Transmembrane / Tyrosine-protein kinase

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