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-Structure paper
Title | Discovery of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines: Potent inhibitors of the IGF-1R receptor tyrosine kinase. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 19, Page 469-473, Year 2009 |
Publish date | Sep 19, 2008 (structure data deposition date) |
![]() | Chamberlain, S.D. / Wilson, J.W. / Deanda, F. / Patnaik, S. / Redman, A.M. / Yang, B. / Shewchuk, L. / Sabbatini, P. / Leesnitzer, M.A. / Groy, A. ...Chamberlain, S.D. / Wilson, J.W. / Deanda, F. / Patnaik, S. / Redman, A.M. / Yang, B. / Shewchuk, L. / Sabbatini, P. / Leesnitzer, M.A. / Groy, A. / Atkins, C. / Gerding, R. / Hassell, A.M. / Lei, H. / Mook, R.A. / Moorthy, G. / Rowand, J.L. / Stevens, K.L. / Kumar, R. / Shotwell, J.B. |
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Methods | X-ray diffraction |
Resolution | 2.1 Å |
Structure data | ![]() PDB-3ekk: |
Chemicals | ![]() ChemComp-GS2: ![]() ChemComp-HOH: |
Source |
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![]() | TRANSFERASE / insulin / tyrosine kinase / ATP-binding / Carbohydrate metabolism / Cleavage on pair of basic residues / Diabetes mellitus / Disease mutation / Glycoprotein / Kinase / Membrane / Nucleotide-binding / Phosphoprotein / Receptor / Transmembrane / Tyrosine-protein kinase |