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Structure paper

TitleFragment-based discovery of JAK-2 inhibitors.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 19, Page 279-282, Year 2009
Publish dateAug 14, 2008 (structure data deposition date)
AuthorsAntonysamy, S. / Hirst, G. / Park, F. / Sprengeler, P. / Stappenbeck, F. / Steensma, R. / Wilson, M. / Wong, M.
External linksBioorg. Med. Chem. Lett. / PubMed:19019674
MethodsX-ray diffraction
Resolution1.8 - 1.922 Å
Structure data

PDB-3e62:
Fragment based discovery of JAK-2 inhibitors
Method: X-RAY DIFFRACTION / Resolution: 1.922 Å

PDB-3e63:
Fragment based discovery of JAK-2 inhibitors
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-3e64:
Fragment based discovery of JAK-2 inhibitors
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-5B1:
5-bromo-1H-indazol-3-amine

ChemComp-HOH:
WATER

ChemComp-5B2:
5-phenyl-1H-indazol-3-amine

ChemComp-5B3:
4-(3-amino-1H-indazol-5-yl)-N-tert-butylbenzenesulfonamide

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / DRUG DISCOVERY / JAK2 / FRAGMENT BASED / ATP-binding / Disease mutation / Kinase / Membrane / Nucleotide-binding / Phosphoprotein / Proto-oncogene / SH2 domain / Tyrosine-protein kinase

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