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TitlePyrido[2,3-d]pyrimidin-5-ones: a novel class of antiinflammatory macrophage colony-stimulating factor-1 receptor inhibitors
Journal, issue, pagesJ. Med. Chem., Vol. 52, Page 1081-1099, Year 2009
Publish dateJul 8, 2008 (structure data deposition date)
AuthorsHuang, H. / Hutta, D.A. / Rinker, J.M. / Hu, H. / Parsons, W.H. / Schubert, C. / DesJarlais, R.L. / Crysler, C.S. / Chaikin, M.A. / Donatelli, R.R. ...Huang, H. / Hutta, D.A. / Rinker, J.M. / Hu, H. / Parsons, W.H. / Schubert, C. / DesJarlais, R.L. / Crysler, C.S. / Chaikin, M.A. / Donatelli, R.R. / Chen, Y. / Cheng, D. / Zhou, Z. / Yurkow, E. / Manthey, C.L. / Player, M.R.
External linksJ. Med. Chem. / PubMed:19193011
MethodsX-ray diffraction
Resolution1.95 Å
Structure data

PDB-3dpk:
cFMS tyrosine kinase in complex with a pyridopyrimidinone inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-8C5:
8-cyclohexyl-N-methoxy-5-oxo-2-{[4-(2-pyrrolidin-1-ylethyl)phenyl]amino}-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / RECEPTOR TYROSINE KINASE / KINASE-INHIBITOR COMPLEX / ATP-binding / Glycoprotein / Immunoglobulin domain / Kinase / Membrane / Nucleotide-binding / Phosphoprotein / Proto-oncogene / Receptor / Transmembrane / Tyrosine-protein kinase / Craniosynostosis / Disease mutation / Dwarfism / Heparin-binding / Kallmann syndrome

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