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Structure paper

TitleTopology conservation and loop flexibility in quadruplex-drug recognition: crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes
Journal, issue, pagesJ. Mol. Biol., Vol. 381, Page 1145-1156, Year 2008
Publish dateFeb 26, 2008 (structure data deposition date)
AuthorsParkinson, G.N. / Cuenca, F. / Neidle, S.
External linksJ. Mol. Biol. / PubMed:18619463
MethodsX-ray diffraction
Resolution2.1 - 2.2 Å
Structure data

PDB-3cco:
Structural adaptation and conservation in quadruplex-drug recognition
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-3cdm:
Structural adaptation and conservation in quadruplex-drug recognition
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-NA:
Unknown entry

ChemComp-K:
Unknown entry

ChemComp-NII:
2,7-bis[3-(dimethylamino)propyl]-4,9-bis[(3-hydroxypropyl)amino]benzo[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetrone

ChemComp-HOH:
WATER

KeywordsDNA / QUADRUPLEX / PROPELLER / DIMERIC / HUMAN TELOMERE PARALLEL STRANDED / LIGAND / COMPLEX / naphthalene diimidine / INTRAMOLECULAR

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