+Search query
-Structure paper
Title | The design and synthesis of diaryl ether second generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with enhanced potency versus key clinical mutations. |
---|---|
Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 18, Page 2959-2966, Year 2008 |
Publish date | Feb 5, 2008 (structure data deposition date) |
Authors | Tucker, T.J. / Saggar, S. / Sisko, J.T. / Tynebor, R.M. / Williams, T.M. / Felock, P.J. / Flynn, J.A. / Lai, M.T. / Liang, Y. / McGaughey, G. ...Tucker, T.J. / Saggar, S. / Sisko, J.T. / Tynebor, R.M. / Williams, T.M. / Felock, P.J. / Flynn, J.A. / Lai, M.T. / Liang, Y. / McGaughey, G. / Liu, M. / Miller, M. / Moyer, G. / Munshi, V. / Perlow-Poehnelt, R. / Prasad, S. / Sanchez, R. / Torrent, M. / Vacca, J.P. / Wan, B.L. / Yan, Y. |
External links | Bioorg. Med. Chem. Lett. / PubMed:18396399 |
Methods | X-ray diffraction |
Resolution | 2.7 Å |
Structure data | PDB-3c6t: PDB-3c6u: |
Chemicals | ChemComp-M14: ChemComp-HOH: ChemComp-M22: |
Source |
|
Keywords | TRANSFERASE / HIV-1 reverse transcriptase / non-nucleoside inhibition / nucleotidyltrasferase / AIDS / Aspartyl protease / Capsid maturation / Capsid protein / Cytoplasm / DNA integration / DNA recombination / DNA-directed DNA polymerase / Endonuclease / Host-virus interaction / Hydrolase / Lipoprotein / Magnesium / Membrane / Metal-binding / Multifunctional enzyme / Myristate / Nuclease / Nucleotidyltransferase / Nucleus / Phosphoprotein / Protease / RNA-binding / RNA-directed DNA polymerase / Viral nucleoprotein / Virion / Zinc / Zinc-finger |