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TitleStructural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 107, Page 13666-13671, Year 2010
Publish dateApr 20, 2010 (structure data deposition date)
AuthorsNishimura, A. / Kitano, K. / Takasaki, J. / Taniguchi, M. / Mizuno, N. / Tago, K. / Hakoshima, T. / Itoh, H.
External linksProc. Natl. Acad. Sci. USA / PubMed:20639466
MethodsX-ray diffraction
Resolution2.9 Å
Structure data

PDB-3ah8:
Structure of heterotrimeric G protein Galpha-q beta gamma in complex with an inhibitor YM-254890
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

Source
  • rattus norvegicus (Norway rat)
  • mus musculus (house mouse)
  • bos taurus (domestic cattle)
  • chromobacterium sp. (bacteria)
KeywordsSIGNALING PROTEIN/INHIBITOR / Heterotrimeric G protein / GTPase / Galpha-q / Gbeta / Ggamma / Inhibitor / YM-254890 / SIGNALING PROTEIN / SIGNALING PROTEIN-INHIBITOR complex

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