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TitlePentameric Ligand-Gated Ion Channel Elic is Activated by Gaba and Modulated by Benzodiazepines.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 109, Page E3028-, Year 2012
Publish dateOct 23, 2012 (structure data deposition date)
AuthorsSpurny, R. / Ramerstorfer, J. / Price, K. / Brams, M. / Ernst, M. / Nury, H. / Verheij, M. / Legrand, P. / Bertrand, D. / Bertrand, S. ...Spurny, R. / Ramerstorfer, J. / Price, K. / Brams, M. / Ernst, M. / Nury, H. / Verheij, M. / Legrand, P. / Bertrand, D. / Bertrand, S. / Dougherty, D.A. / De Esch, I.J.P. / Corringer, P. / Sieghart, W. / Lummis, S.C.R. / Ulens, C.
External linksProc. Natl. Acad. Sci. USA / PubMed:23035248
MethodsX-ray diffraction
Resolution3.343 - 3.9 Å
Structure data

PDB-2yoe:
X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) in complex with GABA and flurazepam
Method: X-RAY DIFFRACTION / Resolution: 3.9 Å

PDB-4a97:
X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) in complex with zopiclone
Method: X-RAY DIFFRACTION / Resolution: 3.343 Å

PDB-4a98:
X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) in complex with bromoflurazepam
Method: X-RAY DIFFRACTION / Resolution: 3.61 Å

Chemicals

ChemComp-ABU:
GAMMA-AMINO-BUTANOIC ACID / neurotransmitter, inhibitor*YM

ChemComp-FL7:
Flurazepam

ChemComp-ZPC:
(5R)-6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate

ChemComp-BFZ:
7-BROMO-1-[2-(DIETHYLAMINO)ETHYL]-5-(2-FLUOROPHENYL)-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE

Source
  • erwinia chrysanthemi (bacteria)
KeywordsTRANSPORT PROTEIN / CYS-LOOP RECEPTOR / GABA-A RECEPTOR / BENZODIAZEPINE

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