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Structure paper

TitleTwo Distinct Conformations of Helix 6 Observed in Antagonist-Bound Structures of a Beta-1- Adrenergic Receptor.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 108, Page 8228-, Year 2011
Publish dateMar 17, 2011 (structure data deposition date)
AuthorsMoukhametzianov, R. / Warne, T. / Edwards, P.C. / Serrano-Vega, M.J. / Leslie, A.G. / Tate, C.G. / Schertler, G.F.
External linksProc. Natl. Acad. Sci. USA / PubMed:21540331
MethodsX-ray diffraction
Resolution3 - 3.65 Å
Structure data

PDB-2ycw:
TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND ANTAGONIST CARAZOLOL
Method: X-RAY DIFFRACTION / Resolution: 3 Å

PDB-2ycx:
TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND ANTAGONIST CYANOPINDOLOL
Method: X-RAY DIFFRACTION / Resolution: 3.25 Å

PDB-2ycy:
TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND ANTAGONIST CYANOPINDOLOL
Method: X-RAY DIFFRACTION / Resolution: 3.15 Å

PDB-2ycz:
TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND ANTAGONIST IODOCYANOPINDOLOL
Method: X-RAY DIFFRACTION / Resolution: 3.65 Å

Chemicals

ChemComp-CAU:
(2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol

ChemComp-2CV:
HEGA-10 / detergent*YM

ChemComp-NA:
Unknown entry

ChemComp-P32:
4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile

ChemComp-SOG:
octyl 1-thio-beta-D-glucopyranoside / detergent*YM

ChemComp-HOH:
WATER

ChemComp-I32:
4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3-iodo-1H-indole-2-carbonitrile / antagonist*YM

Source
  • meleagris gallopavo (turkey)
KeywordsRECEPTOR / GPCR / TRANSDUCER / ANTAGONIST BOUND FORM / INTEGRAL MEMBRANE PROTEIN / G-PROTEIN COUPLED RECEPTOR / THERMOSTABILISING POINT MUTATIONS / SEVEN-HELIX RECEPTOR / 7TM RECEPTOR

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