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TitleSubstrate Recognition by the Multifunctional Cytochrome P450 Mycg in Mycinamicin Hydroxylation and Epoxidation Reactions.
Journal, issue, pagesJ. Biol. Chem., Vol. 287, Page 37880-, Year 2012
Publish dateJan 5, 2011 (structure data deposition date)
AuthorsLi, S. / Tietz, D.R. / Rutaganira, F.U. / Kells, P.M. / Anzai, Y. / Kato, F. / Pochapsky, T.C. / Sherman, D.H. / Podust, L.M.
External linksJ. Biol. Chem. / PubMed:22952225
MethodsX-ray diffraction
Resolution1.62 - 2.39 Å
Structure data

PDB-2y46:
Structure of the mixed-function P450 MycG in complex with mycinamicin IV in C 2 2 21 space group
Method: X-RAY DIFFRACTION / Resolution: 1.83 Å

PDB-2y5n:
Structure of the mixed-function P450 MycG in complex with mycinamicin V in P21 space group
Method: X-RAY DIFFRACTION / Resolution: 1.62 Å

PDB-2y5z:
Mixed-function P450 MycG in complex with mycinamicin III in C2221 space group
Method: X-RAY DIFFRACTION / Resolution: 2.06 Å

PDB-2y98:
Structure of the mixed-function P450 MycG in complex with mycinamicin IV in P21212 space group
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

PDB-2yca:
Mixed-function P450 MycG in complex with mycinamicin III in P21212 space group
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-2ygx:
Structure of the mixed-function P450 MycG in P21 space group
Method: X-RAY DIFFRACTION / Resolution: 2.39 Å

PDB-3zsn:
Structure of the mixed-function P450 MycG F286A mutant in complex with mycinamicin IV
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-4aw3:
Structure of the mixed-function P450 MycG F286V mutant in complex with mycinamicin V in P1 space group
Method: X-RAY DIFFRACTION / Resolution: 2.05 Å

Chemicals

ChemComp-HEM:
PROTOPORPHYRIN IX CONTAINING FE

ChemComp-MIV:
MYCINAMICIN IV

ChemComp-BEN:
BENZAMIDINE

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-MYV:
MYCINAMICIN V

ChemComp-MG:
Unknown entry

ChemComp-ZM3:
MYCINAMICIN III

ChemComp-CL:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-SIN:
SUCCINIC ACID

Source
  • micromonospora griseorubida (bacteria)
KeywordsOXIDOREDUCTASE / MYCINAMICIN BIOSYNTHESIS / ELECTRON TRANSPORT / METAL BINDING

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