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Structure paper

TitleThe Structural Basis for Agonist and Partial Agonist Action on a Beta1-Adrenergic Receptor
Journal, issue, pagesNature, Vol. 469, Page 241-, Year 2011
Publish dateNov 30, 2010 (structure data deposition date)
AuthorsWarne, A. / Moukhametzianov, R. / Baker, J.G. / Nehme, R. / Edwards, P.C. / Leslie, A.G.W. / Schertler, G.F.X. / Tate, C.G.
External linksNature / PubMed:21228877
MethodsX-ray diffraction
Resolution2.5 - 3.05 Å
Structure data

PDB-2y00:
TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND PARTIAL AGONIST DOBUTAMINE (CRYSTAL DOB92)
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-2y01:
TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND PARTIAL AGONIST DOBUTAMINE (CRYSTAL DOB102)
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-2y02:
TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND AGONIST CARMOTEROL
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-2y03:
TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND AGONIST ISOPRENALINE
Method: X-RAY DIFFRACTION / Resolution: 2.85 Å

PDB-2y04:
TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND PARTIAL AGONIST SALBUTAMOL
Method: X-RAY DIFFRACTION / Resolution: 3.05 Å

Chemicals

ChemComp-Y01:
CHOLESTEROL HEMISUCCINATE

ChemComp-2CV:
HEGA-10 / detergent*YM

ChemComp-Y00:
DOBUTAMINE / medication*YM

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-WHJ:
CARMOTEROL / medication, agonist*YM

ChemComp-5FW:
ISOPRENALINE / medication*YM

ChemComp-68H:
SALBUTAMOL / medication, agonist*YM

Source
  • meleagris gallopavo (turkey)
KeywordsRECEPTOR / G PROTEIN COUPLED RECEPTOR / SEVEN-HELIX RECEPTOR / INTEGRAL MEMBRANE PROTEIN / THERMOSTABILISING POINT MUTATIONS / GPCR / 7TM RECEPTOR

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