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-Structure paper
Title | A Selective Jumonji H3K27 Demethylase Inhibitor Modulates the Proinflammatory Macrophage Response |
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Journal, issue, pages | Nature, Vol. 488, Page 404-, Year 2012 |
Publish date | Oct 19, 2010 (structure data deposition date) |
Authors | Kruidenier, L. / Chung, C. / Cheng, Z. / Liddle, J. / Che, K. / Joberty, G. / Bantscheff, M. / Bountra, C. / Bridges, A. / Diallo, H. ...Kruidenier, L. / Chung, C. / Cheng, Z. / Liddle, J. / Che, K. / Joberty, G. / Bantscheff, M. / Bountra, C. / Bridges, A. / Diallo, H. / Eberhard, D. / Hutchinson, S. / Jones, E. / Katso, R. / Leveridge, M. / Mander, P.K. / Mosley, J. / Ramirez-Molina, C. / Rowland, P. / Schofield, C.J. / Sheppard, R.J. / Smith, J.E. / Swales, C. / Tanner, R. / Thomas, P. / Tumber, A. / Drewes, G. / Oppermann, U. / Patel, D.J. / Lee, K. / Wilson, D.M. |
External links | Nature / PubMed:22842901 |
Methods | X-ray diffraction |
Resolution | 1.86 - 2.99 Å |
Structure data | PDB-2xue: PDB-4ask: PDB-4eyu: PDB-4ez4: PDB-4ezh: |
Chemicals | ChemComp-ZN: ChemComp-SO4: ChemComp-FE: ChemComp-AKG: ChemComp-HOH: ChemComp-K0I: ChemComp-CO: ChemComp-OGA: ChemComp-NI: |
Source |
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Keywords | OXIDOREDUCTASE / HISTONE METHYLASE / KDM6B / GSK-J1 / INHIBITOR / LYSINE SPECIFIC HISTONE DEMETHYLASE / JMJC domain / Histone K27 trimethyl and dimethyl demethylase / mjd3/KDM6B / histone demethylase / JmjC / histone K27me3/me2 'eraser' |