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TitleNovel Thienopyrimidine and Thiazolopyrimidine Kinase Inhibitors with Activity Against Tie-2 in Vitro and in Vivo.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 19, Page 6670-, Year 2009
Publish dateAug 18, 2009 (structure data deposition date)
AuthorsLuke, R.W. / Ballard, P. / Buttar, D. / Campbell, L. / Curwen, J. / Emery, S.C. / Griffen, A.M. / Hassall, L. / Hayter, B.R. / Jones, C.D. ...Luke, R.W. / Ballard, P. / Buttar, D. / Campbell, L. / Curwen, J. / Emery, S.C. / Griffen, A.M. / Hassall, L. / Hayter, B.R. / Jones, C.D. / Mccoull, W. / Mellor, M. / Swain, M.L. / Tucker, J.A.
External linksBioorg. Med. Chem. Lett. / PubMed:19854647
MethodsX-ray diffraction
Resolution2.95 Å
Structure data

PDB-2wqb:
Structure of the Tie2 kinase domain in complex with a thiazolopyrimidine inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.95 Å

Chemicals

ChemComp-QQ1:
2-[3-(CYCLOHEXYLMETHYL)-5-PHENYL-IMIDAZOL-4-YL]-[1,3]THIAZOLO[4,5-E]PYRIMIDIN-7-AMINE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / PHOSPHOPROTEIN / KINASE / RECEPTOR / ONCOLOGY / ATP-BINDING / GLYCOPROTEIN / TYROSINE-PROTEIN KINASE / PHOSPHOTRANSFERASE / NUCLEOTIDE-BINDING / DISEASE MUTATION / THIAZOLOPYRIMIDINE

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