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TitleThe Glutamate Receptor Glur5 Agonist (S)-2-Amino-3-(3-Hydroxy-7,8-Dihydro-6H-Cyclohepta[D]Isoxazol-4-Yl)Propionic Acid and the 8-Methyl Analogue: Synthesis, Molecular Pharmacology, and Biostructural Characterization
Journal, issue, pagesJ. Med. Chem., Vol. 52, Page 4911-, Year 2009
Publish dateJun 18, 2009 (structure data deposition date)
AuthorsClausen, R.P. / Naur, P. / Kristensen, A.S. / Greenwood, J.R. / Strange, M. / Brauner-Osborne, H. / Jensen, A.A. / Nielsen, A.S. / Geneser, U. / Ringgaard, L.M. ...Clausen, R.P. / Naur, P. / Kristensen, A.S. / Greenwood, J.R. / Strange, M. / Brauner-Osborne, H. / Jensen, A.A. / Nielsen, A.S. / Geneser, U. / Ringgaard, L.M. / Nielsen, B. / Pickering, D.S. / Brehm, L. / Gajhede, M. / Krogsgaard-Larsen, P. / Kastrup, J.S.
External linksJ. Med. Chem. / PubMed:19588945
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-2wky:
Crystal structure of the ligand-binding core of GluR5 in complex with the agonist 4-AHCP
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-CL:
Unknown entry

ChemComp-IBC:
3-(3-HYDROXY-7,8-DIHYDRO-6H-CYCLOHEPTA[D]ISOXAZOL-4-YL)-L-ALANINE

ChemComp-HOH:
WATER

Source
  • rattus norvegicus (Norway rat)
KeywordsMEMBRANE PROTEIN / SYNAPSE / MEMBRANE / RECEPTOR / TRANSPORT / ION CHANNEL / RNA EDITING / GLYCOPROTEIN / CELL JUNCTION / IONOTROPIC GLUTAMATE RECEPTOR / ALTERNATIVE SPLICING / POSTSYNAPTIC CELL MEMBRANE / IONIC CHANNEL / CELL MEMBRANE / ION TRANSPORT / TRANSMEMBRANE / PHOSPHOPROTEIN / LIGAND-BINDING CORE

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