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Title | Binding and Inactivation Mechanism of a Humanized Fatty Acid Amide Hydrolase by Alpha-Ketoheterocycle Inhibitors Revealed from Cocrystal Structures. |
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Journal, issue, pages | J. Am. Chem. Soc., Vol. 131, Page 10497-, Year 2009 |
Publish date | May 19, 2009 (structure data deposition date) |
![]() | Mileni, M. / Garfunkle, J. / Demartino, J.K. / Cravatt, B.F. / Boger, D.L. / Stevens, R.C. |
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Methods | X-ray diffraction |
Resolution | 1.84 - 2.55 Å |
Structure data | ![]() PDB-2wj1: ![]() PDB-2wj2: |
Chemicals | ![]() ChemComp-S99: ![]() ChemComp-CL: ![]() ChemComp-HOH: ![]() ChemComp-OL1: |
Source |
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![]() | HYDROLASE / MONOTOPIC MEMBRANE PROTEIN / FATTY ACID AMIDE HYDROLASE / GOLGI APPARATUS / ENDOPLASMIC RETICULUM / MEMBRANE / TRANSMEMBRANE / PHOSPHOPROTEIN / COVALENT REVERSIBLE INHIBITOR / COVALENT REVERSIBLE INHIBITORS / ALPHA-KETOOXAZOLE |