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Structure paper

TitleMolecular Basis of Drug Resistance in Aurora Kinases.
Journal, issue, pagesChem. Biol., Vol. 15, Page 552-, Year 2008
Publish dateApr 16, 2008 (structure data deposition date)
AuthorsGirdler, F. / Sessa, F. / Patercoli, S. / Villa, F. / Musacchio, A. / Taylor, S.S.
External linksChem. Biol. / PubMed:18559266
MethodsX-ray diffraction
Resolution1.86 Å
Structure data

PDB-2vrx:
Structure of Aurora B kinase in complex with ZM447439
Method: X-RAY DIFFRACTION / Resolution: 1.86 Å

Chemicals

ChemComp-447:
N-(4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazolin-4-yl]amino}phenyl)benzamide / inhibitor*YM

ChemComp-HOH:
WATER

Source
  • xenopus laevis (African clawed frog)
KeywordsCELL CYCLE/TRANSFERASE / SERINE/THREONINE-PROTEIN KINASE / KINASE / NUCLEUS / MITOSIS / MAGNESIUM / CENTROMERE / MICROTUBULE / ATP-BINDING / TRANSFERASE / ANTI-CANCER DRUG TARGET / PHOSPHOPROTEIN / PROTEIN KINASE / NUCLEOTIDE-BINDING / COILED COIL / CELL DIVISION / METAL-BINDING / CELL CYCLE-TRANSFERASE complex

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