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TitleReversine, a Novel Aurora Kinases Inhibitor, Inhibits Colony Formation of Human Acute Myeloid Leukemia Cells.
Journal, issue, pagesMol. Cancer Ther., Vol. 7, Page 1140-, Year 2008
Publish dateNov 15, 2007 (structure data deposition date)
AuthorsD'Alise, A.M. / Amabile, G. / Iovino, M. / Di Giorgio, F.P. / Bartiromo, M. / Sessa, F. / Villa, F. / Musacchio, A. / Cortese, R.
External linksMol. Cancer Ther. / PubMed:18483302
MethodsX-ray diffraction
Resolution1.7 Å
Structure data

PDB-2vgo:
Crystal structure of Aurora B kinase in complex with Reversine inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-AD5:
N~6~-cyclohexyl-N~2~-(4-morpholin-4-ylphenyl)-9H-purine-2,6-diamine / antagonist*YM

ChemComp-HOH:
WATER

Source
  • xenopus laevis (African clawed frog)
KeywordsTRANSFERASE / NUCLEOTIDE-BINDING / SERINE/THREONINE-PROTEIN KINASE / ATP-BINDING / COILED COIL / CELL DIVISION / KINASE / CANCER / INCENP / NUCLEUS / MITOSIS / AURORA B / METAL-BINDING / AMINOTHIAZOLE / PHOSPHORYLATION / MAGNESIUM / CELL CYCLE / CENTROMERE / MICROTUBULE

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