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-Structure paper
Title | Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme. |
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Journal, issue, pages | Nucleic Acids Res., Vol. 35, Page 6424-6438, Year 2007 |
Publish date | May 25, 2007 (structure data deposition date) |
![]() | Li, F. / Pallan, P.S. / Maier, M.A. / Rajeev, K.G. / Mathieu, S.L. / Kreutz, C. / Fan, Y. / Sanghvi, J. / Micura, R. / Rozners, E. ...Li, F. / Pallan, P.S. / Maier, M.A. / Rajeev, K.G. / Mathieu, S.L. / Kreutz, C. / Fan, Y. / Sanghvi, J. / Micura, R. / Rozners, E. / Manoharan, M. / Egli, M. |
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Methods | X-ray diffraction |
Resolution | 1.1 - 1.12 Å |
Structure data | ![]() PDB-2q1o: ![]() PDB-2q1r: |
Chemicals | ![]() ChemComp-HOH: ![]() ChemComp-MG: |
![]() | RNA / 2 / 4-Difluorotoluyl Nucleoside / Chemical Modification / RNAi / Hydrogen Bond / G-A mismatch |