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Structure paper

TitleGABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop.
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 14, Page 280-286, Year 2007
Publish dateJan 17, 2007 (structure data deposition date)
AuthorsFenalti, G. / Law, R.H.P. / Buckle, A.M. / Langendorf, C. / Tuck, K. / Rosado, C.J. / Faux, N.G. / Mahmood, K. / Hampe, C.S. / Banga, J.P. ...Fenalti, G. / Law, R.H.P. / Buckle, A.M. / Langendorf, C. / Tuck, K. / Rosado, C.J. / Faux, N.G. / Mahmood, K. / Hampe, C.S. / Banga, J.P. / Wilce, M. / Schmidberger, J. / Rossjohn, J. / El-Kabbani, O. / Pike, R.N. / Smith, A.I. / Mackay, I.R. / Rowley, M.J. / Whisstock, J.C.
External linksNat. Struct. Mol. Biol. / PubMed:17384644
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-2okj:
The X-ray crystal structure of the 67kDa isoform of Glutamic Acid Decarboxylase (GAD67)
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-2okk:
The X-ray crystal structure of the 65kDa isoform of Glutamic Acid Decarboxylase (GAD65)
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-ABU:
GAMMA-AMINO-BUTANOIC ACID / neurotransmitter, inhibitor*YM

ChemComp-PLZ:
4-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]BUTANOIC ACID

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

Source
  • homo sapiens (human)
KeywordsLYASE / PLP-dependent decarboxylase

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