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| Title | Discovery of Aminoquinazolines as Potent, Orally Bioavailable Inhibitors of Lck: Synthesis, SAR, and in Vivo Anti-Inflammatory Activity |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 49, Page 5671-, Year 2006 |
| Publish date | Jan 4, 2007 (structure data deposition date) |
 Authors | DiMauro, E.F. / Newcomb, J. / Nunes, J.J. / Bemis, J.E. / Boucher, C. / Buchanan, J.L. / Buckner, W.H. / Cee, V.J. / Chai, L. / Deak, H.L. ...DiMauro, E.F. / Newcomb, J. / Nunes, J.J. / Bemis, J.E. / Boucher, C. / Buchanan, J.L. / Buckner, W.H. / Cee, V.J. / Chai, L. / Deak, H.L. / Epstein, L.F. / Faust, T. / Gallant, P. / Geuns-Meyer, S.D. / Gore, A. / Gu, Y. / Henkle, B. / Hodous, B.L. / Hsieh, F. / Huang, X. / Kim, J.L. / Lee, J.H. / Martin, M.W. / Masse, C.E. / McGowan, D.C. / Metz, D. / Mohn, D. / Morgenstern, K.A. / Oliveira-dos-Santos, A. / Patel, V.F. / Powers, D. / Rose, P.E. / Schneider, S. / Tomlinson, S.A. / Tudor, Y.-Y. / Turci, S.M. / Welcher, A.A. / White, R.D. / Zhao, H. / Zhu, L. / Zhu, X. |
 External links | J. Med. Chem. / PubMed:16970394 |
| Methods | X-ray diffraction |
| Resolution | 2 - 2.3 Å |
| Structure data |  PDB-2ofv:  PDB-2og8: |
| Chemicals |  ChemComp-242:  ChemComp-HOH:  ChemComp-1N8: |
| Source |
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 Keywords | TRANSFERASE / Lck / Kinase domain |
homo sapiens (human)