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TitleStructural basis for DNA cleavage by the potent antiproliferative agent (-)-lomaiviticin A.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 113, Page 2851-2856, Year 2016
Publish dateNov 7, 2015 (structure data deposition date)
AuthorsWoo, C.M. / Li, Z. / Paulson, E.K. / Herzon, S.B.
External linksProc. Natl. Acad. Sci. USA / PubMed:26929332
MethodsNMR (solution)
Structure data

PDB-2n96:
An unexpected mode of small molecule DNA binding provides the structural basis for DNA cleavage by the potent antiproliferative agent (-)-lomaiviticin A
Method: SOLUTION NMR

Chemicals

ChemComp-4JF:
(1R,1'R,2S,2'S,3R,3'R,5aR,10aR,11a'S)-2'-[(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)oxy]-2,2'-diethyl-11,11

Source
  • synthetic construct (others)
KeywordsDNA / diazofluorene / intercalator

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