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Structure paper

TitleStructural insights into the degradation of Mcl-1 induced by BH3 domains
Journal, issue, pagesProc. Natl. Acad. Sci. Usa, Vol. 104, Page 6217-6222, Year 2007
Publish dateOct 17, 2006 (structure data deposition date)
AuthorsCzabotar, P.E. / Lee, E.F. / van Delft, M.F. / Day, C.L. / Smith, B.J. / Huang, D.C.S. / Fairlie, W.D. / Hinds, M.G. / Colman, P.M.
External linksProc. Natl. Acad. Sci. Usa / PubMed:17389404
MethodsNMR (solution) / X-ray diffraction
Resolution1.55 - 2.8 Å
Structure data

PDB-2jm6:
Solution structure of MCL-1 complexed with NOXAB
Method: SOLUTION NMR

PDB-2nl9:
Crystal structure of the Mcl-1:Bim BH3 complex
Method: X-RAY DIFFRACTION / Resolution: 1.55 Å

PDB-2nla:
Crystal structure of the Mcl-1:mNoxaB BH3 complex
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsAPOPTOSIS / MCL-1 / BCL-2 / HELICAL BUNDLE / BH3-ONLY / Bim / Noxa

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