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TitleStructure and Regulation of the Human Nek2 Centrosomal Kinase
Journal, issue, pagesJ. Biol. Chem., Vol. 282, Page 6833-, Year 2007
Publish dateNov 30, 2006 (structure data deposition date)
AuthorsRellos, P. / Ivins, F.J. / Baxter, J.E. / Pike, A.C.W. / Nott, T.J. / Parkinson, D.-M. / Das, S. / Howell, S. / Fedorov, O. / Shen, Q.Y. ...Rellos, P. / Ivins, F.J. / Baxter, J.E. / Pike, A.C.W. / Nott, T.J. / Parkinson, D.-M. / Das, S. / Howell, S. / Fedorov, O. / Shen, Q.Y. / Fry, A.M. / Knapp, S. / Smerdon, S.J.
External linksJ. Biol. Chem. / PubMed:17197699
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-2jav:
Human Kinase with pyrrole-indolinone ligand
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-5Z5:
5-[(Z)-(5-CHLORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-(DIETHYLAMINO)ETHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / PHOSPHORYLATION / NUCLEOTIDE-BINDING / ATP-BINDING / CELL DIVISION / METAL-BINDING / NUCLEAR PROTEIN / SERINE/THREONINE-PROTEIN KINASE / SERINE/THREONINE PROTEIN KINASE / KINASE / MEIOSIS / MITOSIS / MAGNESIUM / CELL CYCLE

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