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Structure paper

TitleEngineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery.
Journal, issue, pagesActa Crystallogr. ,Sect. D, Vol. 62, Page 1435-1445, Year 2006
Publish dateJun 14, 2006 (structure data deposition date)
AuthorsEvdokimov, A.G. / Pokross, M. / Walter, R. / Mekel, M. / Cox, B. / Li, C. / Bechard, R. / Genbauffe, F. / Andrews, R. / Diven, C. ...Evdokimov, A.G. / Pokross, M. / Walter, R. / Mekel, M. / Cox, B. / Li, C. / Bechard, R. / Genbauffe, F. / Andrews, R. / Diven, C. / Howard, B. / Rastogi, V. / Gray, J. / Maier, M. / Peters, K.G.
External linksActa Crystallogr. ,Sect. D / PubMed:17139078
MethodsX-ray diffraction
Resolution1.3 - 2.15 Å
Structure data

PDB-2hc1:
Engineered catalytic domain of protein tyrosine phosphatase HPTPbeta.
Method: X-RAY DIFFRACTION / Resolution: 1.3 Å

PDB-2hc2:
Engineered protein tyrosine phosphatase beta catalytic domain
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

PDB-2i3r:
Engineered catalytic domain of protein tyrosine phosphatase HPTPbeta
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

PDB-2i3u:
Structural studies of protein tyrosine phosphatase beta catalytic domain in complex with inhibitors
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

PDB-2i4e:
Structural studies of protein tyrosine phosphatase beta catalytic domain in complex with inhibitors
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

PDB-2i4g:
Structural studies of protein tyrosine phosphatase beta catalytic domain in complex with a sulfamic acid (soaking experiment)
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

PDB-2i4h:
Structural studies of protein tyrosine phosphatase beta catalytic domain co-crystallized with a sulfamic acid inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

PDB-2i5x:
Engineering the PTPbeta catalytic domain with improved crystallization properties
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-ACT:
ACETATE ION

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-MG:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-VO4:
VANADATE ION

ChemComp-UA1:
N-(TERT-BUTOXYCARBONYL)-L-TYROSYL-N-METHYL-4-(SULFOAMINO)-L-PHENYLALANINAMIDE

ChemComp-UA5:
(4-ETHYLPHENYL)SULFAMIC ACID

Source
  • homo sapiens (human)
KeywordsHYDROLASE / protein tyrosine phosphatase / WPD-loop / sulfamic acid / phosphatase / inhibitor / drug design / protein engineering

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