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Structure paper

TitleCrystal structure of the tyrosine kinase domain of colony-stimulating factor-1 receptor (cFMS) in complex with two inhibitors.
Journal, issue, pagesJ. Biol. Chem., Vol. 282, Page 4094-4101, Year 2007
Publish dateAug 11, 2006 (structure data deposition date)
AuthorsSchubert, C. / Schalk-Hihi, C. / Struble, G.T. / Ma, H.C. / Petrounia, I.P. / Brandt, B. / Deckman, I.C. / Patch, R.J. / Player, M.R. / Spurlino, J.C. / Springer, B.A.
External linksJ. Biol. Chem. / PubMed:17132624
MethodsX-ray diffraction
Resolution1.8 - 2.8 Å
Structure data

PDB-2i0v:
c-FMS tyrosine kinase in complex with a quinolone inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-2i0y:
cFMS tyrosine kinase (FGF KID) in complex with an arylamide inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-2i1m:
cFMS tyrosine kinase (tie2 KID) in complex with an arylamide inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-6C3:
6-CHLORO-3-(3-METHYLISOXAZOL-5-YL)-4-PHENYLQUINOLIN-2(1H)-ONE

ChemComp-HOH:
WATER

ChemComp-5CN:
5-CYANO-FURAN-2-CARBOXYLIC ACID [5-HYDROXYMETHYL-2-(4-METHYL-PIPERIDIN-1-YL)-PHENYL]-AMIDE

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Receptor Tyrosine Kinase / Kinase-Inhibitor complex / Tyrosine Kinase / Kinase Inhibitor Complex / Kinase Domain

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