Database of articles cited by EMDB/PDB/SASBDB data

Keywords
Structure methods	All X-ray diffraction NMR electron microscopy small angle scattering neutron diffraction fiber diffraction powder diffraction infrared spectroscopy EPR fluorescence transfer theoretical model Hybrid
Author
Journal
IF	>30 >20 >10 >5 all

Title	Development of 6-substituted indolylquinolinones as potent Chek1 kinase inhibitors.
Journal, issue, pages	Bioorg. Med. Chem. Lett., Vol. 16, Page 5907-5912, Year 2006
Publish date	Aug 3, 2006 (structure data deposition date)
Authors	Huang, S. / Garbaccio, R.M. / Fraley, M.E. / Steen, J. / Kreatsoulas, C. / Hartman, G. / Stirdivant, S. / Drakas, B. / Rickert, K. / Walsh, E. ...Huang, S. / Garbaccio, R.M. / Fraley, M.E. / Steen, J. / Kreatsoulas, C. / Hartman, G. / Stirdivant, S. / Drakas, B. / Rickert, K. / Walsh, E. / Hamilton, K. / Buser, C.A. / Hardwick, J. / Mao, X. / Abrams, M. / Beck, S. / Tao, W. / Lobell, R. / Sepp-Lorenzino, L. / Yan, Y. / Ikuta, M. / Murphy, J.Z. / Sardana, V. / Munshi, S. / Kuo, L. / Reilly, M. / Mahan, E.
External links	Bioorg. Med. Chem. Lett. / PubMed:16990002
Methods	X-ray diffraction
Resolution	1.7 - 2 Å
Structure data	PDB-2hxl: crystal structure of Chek1 in complex with inhibitor 1 Method: X-RAY DIFFRACTION / Resolution: 1.8 Å PDB-2hxq: crystal structure of Chek1 in complex with inhibitor 2 Method: X-RAY DIFFRACTION / Resolution: 2 Å PDB-2hy0: crystal structure of chek1 in complex with inhibitor 22 Method: X-RAY DIFFRACTION / Resolution: 1.7 Å
Chemicals	ChemComp-422: 3-(5-{[4-(AMINOMETHYL)PIPERIDIN-1-YL]METHYL}-1H-INDOL-2-YL)-1H-INDAZOLE-6-CARBONITRILE ChemComp-HOH: WATER ChemComp-373: 3-(5-{[4-(AMINOMETHYL)PIPERIDIN-1-YL]METHYL}-1H-INDOL-2-YL)QUINOLIN-2(1H)-ONE ChemComp-306: 3-[5-(PIPERIDIN-1-YLMETHYL)-1H-INDOL-2-YL]-6-(1H-PYRAZOL-4-YL)QUINOLIN-2(1H)-ONE
Source	homo sapiens (human)
Keywords	TRANSFERASE / Chek1 / Kinase / cell cycle checkpoint