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Title | Methylene substitution at the alpha-beta bridging position within the phosphate chain of dUDP profoundly perturbs ligand accommodation into the dUTPase active site. |
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Journal, issue, pages | Proteins, Vol. 71, Page 308-319, Year 2008 |
Publish date | Jul 19, 2006 (structure data deposition date) |
![]() | Kovari, J. / Barabas, O. / Varga, B. / Bekesi, A. / Tolgyesi, F. / Fidy, J. / Nagy, J. / Vertessy, B.G. |
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Methods | X-ray diffraction |
Resolution | 1.7 - 1.84 Å |
Structure data | ![]() PDB-2hr6: ![]() PDB-2hrm: |
Chemicals | ![]() ChemComp-MN: ![]() ChemComp-DUD: ![]() ChemComp-EDO: ![]() ChemComp-HOH: ![]() ChemComp-UC5: |
Source |
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![]() | HYDROLASE / JELLY ROLL / ENZYME-LIGAND-metal COMPLEX / ENZYME-SUBSTRATE ANALOGUE LIGAND COMPLEX |