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Structure paper

TitleMultiple Conformations of Phosphodiesterase-5: Implications for enzyme function and drug development
Journal, issue, pagesJ. Biol. Chem., Vol. 281, Page 21469-21479, Year 2006
Publish dateMay 23, 2006 (structure data deposition date)
AuthorsWang, H. / Liu, Y. / Huai, Q. / Cai, J. / Zoraghi, R. / Francis, S.H. / Corbin, J.D. / Robinson, H. / Xin, Z. / Lin, G. / Ke, H.
External linksJ. Biol. Chem. / PubMed:16735511
MethodsX-ray diffraction
Resolution1.8 - 2.3 Å
Structure data

PDB-2h40:
Crystal structure of the catalytic domain of unliganded PDE5
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

PDB-2h42:
Crystal structure of PDE5 in complex with sildenafil
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-2h44:
Crystal structure of PDE5A1 in complex with icarisid II
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-VIA:
5-{2-ETHOXY-5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-1-METHYL-3-PROPYL-1H,6H,7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE / medication*YM

ChemComp-7CA:
5,7-DIHYDROXY-2-(4-METHOXYPHENYL)-8-(3-METHYLBUTYL)-4-OXO-4H-CHROMEN-3-YL 6-DEOXY-ALPHA-L-MANNOPYRANOSIDE

Source
  • homo sapiens (human)
KeywordsHYDROLASE / PDE5 / unliganded / viagra / icarisid II / flavonoid / PDE5A inhibitor

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