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Title | Design, synthesis, evaluation, and crystallographic-based structural studies of HIV-1 protease inhibitors with reduced response to the V82A mutation. |
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Journal, issue, pages | J. Med. Chem., Vol. 51, Page 852-860, Year 2008 |
Publish date | Jan 5, 2006 (structure data deposition date) |
![]() | Clemente, J.C. / Robbins, A. / Grana, P. / Paleo, M.R. / Correa, J.F. / Villaverde, M.C. / Sardina, F.J. / Govindasamy, L. / Agbandje-McKenna, M. / McKenna, R. ...Clemente, J.C. / Robbins, A. / Grana, P. / Paleo, M.R. / Correa, J.F. / Villaverde, M.C. / Sardina, F.J. / Govindasamy, L. / Agbandje-McKenna, M. / McKenna, R. / Dunn, B.M. / Sussman, F. |
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Methods | X-ray diffraction |
Resolution | 1.9 Å |
Structure data | ![]() PDB-2fle: |
Chemicals | ![]() ChemComp-GOL: ![]() ChemComp-AI: ![]() ChemComp-HOH: |
Source |
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![]() | hydrolase/hydrolase inhibitor / HIV-1 protease / inhibitor / resistance / induced fit / hydrolase-hydrolase inhibitor COMPLEX |