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TitleIn the Search of Glycogen Phosphorylase Inhibitors: Synthesis of C-D-Glycopyranosylbenzo(hydro)quinones Inhibition of and Binding to Glycogen Phosphorylase in the Crystal
Journal, issue, pagesEur. J. Org. Chem., Vol. 4, Page 596-606, Year 2007
Publish dateDec 16, 2005 (structure data deposition date)
AuthorsHe, L. / Zhang, Y.Z. / Tanoh, M. / Chen, G.-R. / Praly, J.-P. / Chrysina, E.D. / Tiraidis, C. / Kosmopoulou, M. / Leonidas, D.D. / Oikonomakos, N.G.
External linksEur. J. Org. Chem. / Search PubMed
MethodsX-ray diffraction
Resolution2.03 Å
Structure data

PDB-2fet:
Synthesis of C-D-Glycopyranosyl-Hydroquinones and-Benzoquinones. Inhibition of PTP1B. Inhibition of and binding to glycogen phosphorylase in the crystal
Method: X-RAY DIFFRACTION / Resolution: 2.03 Å

PDB-2ff5:
Synthesis of C-D-Glycopyranosyl-Hydroquinones and-Benzoquinones. Inhibition of PTP1B. Inhibition of and binding to glycogen phosphorylase in the crystal
Method: X-RAY DIFFRACTION / Resolution: 2.03 Å

Chemicals

ChemComp-PLP:
PYRIDOXAL-5'-PHOSPHATE

ChemComp-H53:
(1S)-1,5-anhydro-1-(2,5-dihydroxyphenyl)-D-glucitol

ChemComp-HOH:
WATER

Source
  • oryctolagus cuniculus (rabbit)
KeywordsTRANSFERASE / glycogenolysis; type 2 diabetes

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