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Structure paper

TitleCrystal structures of complexes between aminoglycosides and decoding A site oligonucleotides: role of the number of rings and positive charges in the specific binding leading to miscoding
Journal, issue, pagesNucleic Acids Res., Vol. 33, Page 5677-5790, Year 2005
Publish dateOct 26, 2005 (structure data deposition date)
AuthorsFrancois, B. / Russel, R.J.M. / Murray, J.B. / Aboul-ela, F. / Masquida, B. / Vicens, Q. / Westhof, E.
External linksNucleic Acids Res. / PubMed:16214802
MethodsX-ray diffraction
Resolution2.2 - 3 Å
Structure data

PDB-2esi:
Complex between Kanamycin A and the 16S-Rrna A Site.
Method: X-RAY DIFFRACTION / Resolution: 3 Å

PDB-2esj:
Complex between Lividomycin A and the 16S-Rrna A Site
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-2et3:
Complex Between Gentamicin C1A and the 16S-RRNA A-Site
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-2et4:
Complex Between Neomycin B and the 16S-RRNA A-Site
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-2et5:
Complex Between Ribostamycin and the 16S-RRNA A-Site
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-2et8:
Complex Between Neamine and the 16S-RRNA A-Site
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-KAN:
KANAMYCIN A / antibiotic*YM

ChemComp-HOH:
WATER

ChemComp-LIV:
(2R,3S,4S,5S,6R)-2-((2S,3S,4R,5R,6R)-5-AMINO-2-(AMINOMETHYL)-6-((2R,3S,4R,5S)-5-((1R,2R,3S,5R,6S)-3,5-DIAMINO-2-((2S,3R

ChemComp-LLL:
(2R,3R,4R,5R)-2-((1S,2S,3R,4S,6R)-4,6-DIAMINO-3-((2R,3R,6S)-3-AMINO-6-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-2-HYDR

ChemComp-NMY:
NEOMYCIN / antibiotic*YM

ChemComp-RIO:
RIBOSTAMYCIN / antibiotic*YM

ChemComp-SO4:
SULFATE ION

ChemComp-XXX:
(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside

KeywordsRNA / RNA-AMINOGLYCOSIDE INTERACTIONS / A SITE / UOU PAIRS / AA BULGES

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