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Structure paper

TitleStructural basis for the altered drug sensitivities of non-small cell lung cancer-associated mutants of human epidermal growth factor receptor
Journal, issue, pagesOncogene, Year 2012
Publish dateFeb 6, 2007 (structure data deposition date)
AuthorsYoshikawa, S. / Kukimoto-Niino, M. / Parker, L. / Handa, N. / Terada, T. / Fujimoto, T. / Terazawa, Y. / Wakiyama, M. / Sato, M. / Sano, S. ...Yoshikawa, S. / Kukimoto-Niino, M. / Parker, L. / Handa, N. / Terada, T. / Fujimoto, T. / Terazawa, Y. / Wakiyama, M. / Sato, M. / Sano, S. / Kobayashi, T. / Tanaka, T. / Chen, L. / Liu, Z.J. / Wang, B.C. / Shirouzu, M. / Kawa, S. / Semba, K. / Yamamoto, T. / Yokoyama, S.
External linksOncogene / PubMed:22349823
MethodsX-ray diffraction
Resolution2.34 - 2.84 Å
Structure data

PDB-2eb2:
Crystal structure of mutated EGFR kinase domain (G719S)
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-2eb3:
Crystal structure of mutated EGFR kinase domain (L858R) in complex with AMPPNP
Method: X-RAY DIFFRACTION / Resolution: 2.84 Å

PDB-3ug1:
Crystal structure of the mutated EGFR kinase domain (G719S/T790M) in the apo form
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

PDB-3ug2:
Crystal structure of the mutated EGFR kinase domain (G719S/T790M) in complex with gefitinib
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-3vjn:
Crystal structure of the mutated EGFR kinase domain (G719S/T790M) in complex with AMPPNP.
Method: X-RAY DIFFRACTION / Resolution: 2.34 Å

PDB-3vjo:
Crystal structure of the wild-type EGFR kinase domain in complex with AMPPNP.
Method: X-RAY DIFFRACTION / Resolution: 2.64 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-ANP:
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER / AMP-PNP, energy-carrying molecule analogue*YM

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-IRE:
Gefitinib / medication, inhibitor*YM

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Kinase / Tyrosine-protein kinase / Receptor / Phosphorylation / ATP-binding / Disease mutation / Transmembrane / Cell cycle / EC 2.7.10.1 / Structural Genomics / NPPSFA / National Project on Protein Structural and Functional Analyses / RIKEN Structural Genomics/Proteomics Initiative / RSGI / ATP binding / drug resistance / TRANSFERASE/TRANSFERASE INHIBITOR / TRANSFERASE-TRANSFERASE INHIBITOR complex

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