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TitleCreation and X-ray structure analysis of the tumor necrosis factor receptor-1-selective mutant of a tumor necrosis factor-alpha antagonist
Journal, issue, pagesJ. Biol. Chem., Vol. 283, Page 998-1007, Year 2008
Publish dateJan 9, 2007 (structure data deposition date)
AuthorsShibata, H. / Yoshioka, Y. / Ohkawa, A. / Minowa, K. / Mukai, Y. / Abe, Y. / Taniai, M. / Nomura, T. / Kayamuro, H. / Nabeshi, H. ...Shibata, H. / Yoshioka, Y. / Ohkawa, A. / Minowa, K. / Mukai, Y. / Abe, Y. / Taniai, M. / Nomura, T. / Kayamuro, H. / Nabeshi, H. / Sugita, T. / Imai, S. / Nagano, K. / Yoshikawa, T. / Fujita, T. / Nakagawa, S. / Yamamoto, A. / Ohta, T. / Hayakawa, T. / Mayumi, T. / Vandenabeele, P. / Aggarwal, B.B. / Nakamura, T. / Yamagata, Y. / Tsunoda, S. / Kamada, H. / Tsutsumi, Y.
External linksJ. Biol. Chem. / PubMed:18003610
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-2e7a:
TNF Receptor Subtype One-selective TNF Mutant with Antagonistic Activity
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsCYTOKINE / Tumor necrosis factor / Trimer / antagonistic activity / TNFR1 specific / phage display system

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