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-Structure paper
Title | Complexes of Alkylene-Linked Tacrine Dimers with Torpedo Californica Acetylcholinesterase: Binding of Bis(5)-Tacrine Produces a Dramatic Rearrangement in the Active-Site Gorge. |
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Journal, issue, pages | J. Med. Chem., Vol. 49, Page 5491-, Year 2006 |
Publish date | Feb 15, 2003 (structure data deposition date) |
Authors | Rydberg, E.H. / Brumshtein, B. / Greenblatt, H.M. / Wong, D.M. / Shaya, D. / Williams, L.D. / Carlier, P.R. / Pang, Y.-P. / Silman, I. / Sussman, J.L. |
External links | J. Med. Chem. / PubMed:16942022 |
Methods | X-ray diffraction |
Resolution | 2.15 - 2.5 Å |
Structure data | PDB-1odc: PDB-1ut6: PDB-2ckm: PDB-2cmf: |
Chemicals | ChemComp-NAG: ChemComp-A8B: ChemComp-HOH: ChemComp-A8N: ChemComp-AA7: ChemComp-F11: |
Source |
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Keywords | HYDROLASE / SERINE HYDROLASE / NEUROTRANSMITTER CLEAVAGE / ALZHEIMER'S DISEASE / BIVALENT LIGAND / DUAL-SITE BINDING / INHIBITOR / SERINE ESTERASE SYNAPSE / NERVE / MUSCLE / GPI-ANCHOR NEUROTRANSMITTER DEGRADATION / GLYCOPROTEIN / ACETYLCHOLINESTERASE / TACRINE / AMINE / HETERODIMER / MEMBRANE / SERINE ESTERASE / SYNAPSE / GPI-ANCHOR / LIPOPROTEIN / CHOLINESTERASE / ALTERNATIVE SPLICING / NEUROTRANSMITTER DEGRADATION |