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TitleA Novel Series of Potent and Selective Pde5 Inhibitors with Potential for High and Dose-Independent Oral Bioavailability
Journal, issue, pagesJ. Med. Chem., Vol. 49, Page 3581-, Year 2006
Publish dateMar 15, 2006 (structure data deposition date)
AuthorsAllerton, C.M.N. / Barber, C.G. / Beaumont, K.C. / Brown, D.G. / Cole, S.M. / Ellis, D. / Lane, C.A.L. / Maw, G.N. / Mount, N.M. / Rawson, D.J. ...Allerton, C.M.N. / Barber, C.G. / Beaumont, K.C. / Brown, D.G. / Cole, S.M. / Ellis, D. / Lane, C.A.L. / Maw, G.N. / Mount, N.M. / Rawson, D.J. / Robinson, C.M. / Street, S.D.A. / Summerhill, N.W.
External linksJ. Med. Chem. / PubMed:16759100
MethodsX-ray diffraction
Resolution1.6 Å
Structure data

PDB-2chm:
Crystal structure of N2 substituted pyrazolo pyrimidinones - a flipped binding mode in PDE5
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-3P4:
5-[2-(BUT-3-EN-1-YLOXY)-5-(1-HYDROXYVINYL)PYRIDIN-3-YL]-3-ETHYL-2-(1-ETHYLAZETIDIN-3-YL)-1,2,6,7A-TETRAHYDRO-7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / PHOSPHODIESTERASE 5 / INHIBITOR / CHIMERA / ALLOSTERIC ENZYME / ALTERNATIVE SPLICING / CGMP / CGMP-BINDING / MAGNESIUM / METAL-BINDING / NUCLEOTIDE-BINDING / PHOSPHORYLATION / ZINC / CAMP

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