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TitleDose-Dependant Antithrombotic Activity of an Orally Active Tissue Factor/Factor Viia Inhibitor without Concomitant Enhancement of Bleeding Propensity.
Journal, issue, pagesBioorg. Med. Chem., Vol. 14, Page 5357-, Year 2006
Publish dateAug 11, 2005 (structure data deposition date)
AuthorsGroebke-Zbinden, K. / Banner, D.W. / Hilpert, K. / Himber, J. / Lave, T. / Riederer, M.A. / Stahl, M. / Tschopp, T.B. / Obst-Sander, U.
External linksBioorg. Med. Chem. / PubMed:16621574
MethodsX-ray diffraction
Resolution1.6 Å
Structure data

PDB-2bz6:
Orally available Factor7a inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

Chemicals

ChemComp-346:
(R)-(4-CARBAMIMIDOYL-PHENYLAMINO)-[5-ETHOXY-2-FLUORO-3-[(R)-TETRAHYDRO-FURAN-3-YLOXY]-PHENYL]-ACETIC ACID

ChemComp-SO4:
SULFATE ION

ChemComp-CA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / SERINE PROTEASE / COAGULATION / ENZYME COMPLEX

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