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TitleStructural basis for sequential cleavage of fibrinopeptides upon fibrin assembly.
Journal, issue, pagesBiochemistry, Vol. 45, Page 3588-3597, Year 2006
Publish dateJun 27, 2005 (structure data deposition date)
AuthorsPechik, I. / Yakovlev, S. / Mosesson, M.W. / Gilliland, G.L. / Medved, L.
External linksBiochemistry / PubMed:16533041
MethodsX-ray diffraction
Resolution3.65 Å
Structure data

PDB-2a45:
Crystal structure of the complex between thrombin and the central "E" region of fibrin
Method: X-RAY DIFFRACTION / Resolution: 3.65 Å

Chemicals

ChemComp-0G6:
D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide

ChemComp-PO4:
PHOSPHATE ION

Source
  • homo sapiens (human)
KeywordsHYDROLASE/HYDROLASE INHIBITOR / THROMBIN / FIBRIN / FRAGMENT E / THROMBIN-FIBRIN COMPLEX / COILED COILS / DISULFIDE RINGS / BLOOD CLOTTING / HYDROLASE-HYDROLASE INHIBITOR COMPLEX

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