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Structure paper

TitleLigand-assisted Aggregation of Proteins: DIMERIZATION OF SERUM AMYLOID P COMPONENT BY BIVALENT LIGANDS.
Journal, issue, pagesJ. Biol. Chem., Vol. 280, Page 31999-32008, Year 2005
Publish dateJun 27, 2005 (structure data deposition date)
AuthorsHo, J.G. / Kitov, P.I. / Paszkiewicz, E. / Sadowska, J. / Bundle, D.R. / Ng, K.K.
External linksJ. Biol. Chem. / PubMed:16036920
MethodsX-ray diffraction
Resolution2 - 3 Å
Structure data

PDB-2a3w:
Decameric structure of human serum amyloid P-component bound to Bis-1,2-{[(Z)-2-carboxy-2-methyl-1,3-dioxane]-5-yloxycarbamoyl}-ethane
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-2a3x:
Decameric crystal structure of human serum amyloid P-component bound to Bis-1,2-{[(Z)-2carboxy- 2-methyl-1,3-dioxane]- 5-yloxycarbonyl}-piperazine
Method: X-RAY DIFFRACTION / Resolution: 3 Å

PDB-2a3y:
Pentameric crystal structure of human serum amyloid P-component bound to Bis-1,2-{[(Z)-2carboxy-2-methyl-1,3-dioxane]-5-yloxycarbamoyl}-ethane.
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-CPJ:
BIS-1,2-{[(Z)-2-CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBAMOYL}-ETHANE

ChemComp-HOH:
WATER

ChemComp-CPK:
BIS-1,2-{[(Z)-2CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBONYL}-PIPERAZINE

Source
  • homo sapiens (human)
KeywordsMETAL BINDING PROTEIN / Multivalent ligand complex / multivalent ligand / serum amyloid

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