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Structure paper

TitleMolecular basis for substrate recognition by MTMR2, a myotubularin family phosphoinositide phosphatase
Journal, issue, pagesProc. Natl. Acad. Sci. Usa, Vol. 103, Page 927-932, Year 2006
Publish dateMay 25, 2005 (structure data deposition date)
AuthorsBegley, M.J. / Taylor, G.S. / Brock, M.A. / Ghosh, P. / Woods, V.L. / Dixon, J.E.
External linksProc. Natl. Acad. Sci. Usa / PubMed:16410353
MethodsX-ray diffraction
Resolution1.82 - 1.98 Å
Structure data

PDB-1zsq:
Crystal Structure of MTMR2 in complex with phosphatidylinositol 3-phosphate
Method: X-RAY DIFFRACTION / Resolution: 1.82 Å

PDB-1zvr:
Crystal Structure of MTMR2 in complex with phosphatidylinositol 3,5-bisphosphate
Method: X-RAY DIFFRACTION / Resolution: 1.98 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-PIB:
2-(BUTANOYLOXY)-1-{[(HYDROXY{[2,3,4,6-TETRAHYDROXY-5-(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL)OXY]METHYL}ETHYL

ChemComp-HOH:
WATER

ChemComp-3PI:
(1S)-2-(1-HYDROXYBUTOXY)-1-{[(HYDROXY{[(2R,3S,5R,6S)-2,4,6-TRIHYDROXY-3,5-BIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL)OXY]METHYL}ETHYL BUTYRATE

Source
  • homo sapiens (human)
KeywordsHYDROLASE / Protein-Phospholipid Complex / Protein-Phosphoinositide Complex

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