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TitleStructural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1
Journal, issue, pagesCell(Cambridge,Mass. ), Vol. 120, Page 343-355, Year 2005
Publish dateJan 21, 2005 (structure data deposition date)
AuthorsKrylova, I.N. / Sablin, E.P. / Moore, J. / Xu, R.X. / Waitt, G.M. / MacKay, J.A. / Juzumiene, D. / Bynum, J.M. / Madauss, K. / Montana, V. ...Krylova, I.N. / Sablin, E.P. / Moore, J. / Xu, R.X. / Waitt, G.M. / MacKay, J.A. / Juzumiene, D. / Bynum, J.M. / Madauss, K. / Montana, V. / Lebedeva, L. / Suzawa, M. / Williams, J.D. / Williams, S.P. / Guy, R.K. / Thornton, J.W. / Fletterick, R.J. / Willson, T.M. / Ingraham, H.A.
External linksCell(Cambridge,Mass. ) / PubMed:15707893
MethodsX-ray diffraction
Resolution1.2 - 3 Å
Structure data

PDB-1ymt:
Mouse SF-1 LBD
Method: X-RAY DIFFRACTION / Resolution: 1.2 Å

PDB-1yok:
crystal structure of human LRH-1 bound with TIF-2 peptide and phosphatidylglycerol
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-1yow:
human Steroidogenic Factor 1 LBD with bound Co-factor Peptide
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-DR9:
1-CIS-9-OCTADECANOYL-2-CIS-9-HEXADECANOYL PHOSPHATIDYL GLYCEROL

ChemComp-HOH:
WATER

ChemComp-P6L:
(2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL (8E)-OCTADEC-8-ENOATE / phospholipid*YM

ChemComp-P0E:
PHOSPHATIDYL ETHANOL

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsTRANSCRIPTION / nuclear receptor / SF-1 / ligand-binding domain / ligand / phosphatidyl glycerol / co-repressor peptide / LRH-1 / TIF-1 / phosphatidylglycerol / Steroidogenic factor 1 / SF1 / phospholipid / phosphatidyl ethanolamine

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