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TitleCrystal structure of a soluble CD28-Fab complex.
Journal, issue, pagesNat Immunol, Vol. 6, Issue 3, Page 271-279, Year 2005
Publish dateFeb 6, 2005
AuthorsEdward J Evans / Robert M Esnouf / Raquel Manso-Sancho / Robert J C Gilbert / John R James / Chao Yu / Janet A Fennelly / Cheryl Vowles / Thomas Hanke / Björn Walse / Thomas Hünig / Poul Sørensen / David I Stuart / Simon J Davis /
PubMed AbstractNaive T cell activation requires signaling by the T cell receptor and by nonclonotypic cell surface receptors. The most important costimulatory protein is the monovalent homodimer CD28, which ...Naive T cell activation requires signaling by the T cell receptor and by nonclonotypic cell surface receptors. The most important costimulatory protein is the monovalent homodimer CD28, which interacts with CD80 and CD86 expressed on antigen-presenting cells. Here we present the crystal structure of a soluble form of CD28 in complex with the Fab fragment of a mitogenic antibody. Structural comparisons redefine the evolutionary relationships of CD28-related proteins, antigen receptors and adhesion molecules and account for the distinct ligand-binding and stoichiometric properties of CD28 and the related, inhibitory homodimer CTLA-4. Cryo-electron microscopy-based comparisons of complexes of CD28 with mitogenic and nonmitogenic antibodies place new constraints on models of antibody-induced receptor triggering. This work completes the initial structural characterization of the CD28-CTLA-4-CD80-CD86 signaling system.
External linksNat Immunol / PubMed:15696168
MethodsEM (single particle) / X-ray diffraction
Resolution2.7 - 28.0 Å
Structure data

EMDB-1219:
Crystal structure of a soluble CD28-Fab complex.
Method: EM (single particle) / Resolution: 28.0 Å

PDB-1yjd:
Crystal structure of human CD28 in complex with the Fab fragment of a mitogenic antibody (5.11A1)
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose / N-Acetylglucosamine

ChemComp-HOH:
WATER / Water

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsIMMUNE SYSTEM/SIGNALING PROTEIN / IgSF / CD28 homodimer / IMMUNE SYSTEM-SIGNALING PROTEIN COMPLEX

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