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Structure paper

TitleStructure and function of sedoheptulose-7-phosphate isomerase, a critical enzyme for lipopolysaccharide biosynthesis and a target for antibiotic adjuvants.
Journal, issue, pagesJ. Biol. Chem., Vol. 283, Page 2835-2845, Year 2008
Publish dateAug 19, 2004 (structure data deposition date)
AuthorsTaylor, P.L. / Blakely, K.M. / de Leon, G.P. / Walker, J.R. / McArthur, F. / Evdokimova, E. / Zhang, K. / Valvano, M.A. / Wright, G.D. / Junop, M.S.
External linksJ. Biol. Chem. / PubMed:18056714
MethodsX-ray diffraction
Resolution1.95 - 2.8 Å
Structure data

PDB-1x92:
CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA PHOSPHOHEPTOSE ISOMERASE IN COMPLEX WITH REACTION PRODUCT D-GLYCERO-D-MANNOPYRANOSE-7-PHOSPHATE
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-2i22:
Crystal structure of Escherichia coli phosphoheptose isomerase in complex with reaction substrate sedoheptulose 7-phosphate
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-2i2w:
Crystal Structure of Escherichia Coli Phosphoheptose Isomerase
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-3bjz:
Crystal structure of Pseudomonas aeruginosa phosphoheptose isomerase
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-M7P:
7-O-phosphono-D-glycero-alpha-D-manno-heptopyranose

ChemComp-HOH:
WATER

ChemComp-I22:
D-ALTRO-HEPT-2-ULOSE 7-PHOSPHATE

ChemComp-GOL:
GLYCEROL

ChemComp-SO4:
SULFATE ION

ChemComp-CL:
Unknown entry

Source
  • pseudomonas aeruginosa (bacteria)
  • escherichia coli (E. coli)
  • pseudomonas aeruginosa pao1 (bacteria)
KeywordsISOMERASE / MIDWEST CENTRE FOR STRUCTURAL GENOMICS / SIS Domain / a/b protein / lipopolysaccharide biosynthesis / PSI / Protein Structure Initiative / Midwest Center for Structural Genomics / MCSG / phosphoheptose isomerase / alpha/beta PROTEIN / Carbohydrate metabolism / Cytoplasm

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