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TitleA Mechanism for the Potent Inhibition of Eukaryotic Acetyl-Coenzyme a Carboxylase by Soraphen A, a Macrocyclic Polyketide Natural Product
Journal, issue, pagesMol. Cell, Vol. 16, Page 881-, Year 2004
Publish dateOct 5, 2004 (structure data deposition date)
AuthorsShen, Y. / Volrath, S.L. / Weatherly, S.C. / Elich, T.D. / Tong, L.
External linksMol. Cell / PubMed:15610732
MethodsX-ray diffraction
Resolution1.8 - 2.5 Å
Structure data

PDB-1w93:
Crystal Structure of Biotin Carboxylase Domain of Acetyl-Coenzyme A Carboxylase from Saccharomyces cerevisiae
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-1w96:
Crystal Structure of Biotin Carboxylase Domain of Acetyl-coenzyme A Carboxylase from Saccharomyces cerevisiae in Complex with Soraphen A
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-S1A:
SORAPHEN A

Source
  • saccharomyces cerevisiae (brewer's yeast)
KeywordsLIGASE / OBESITY / DIABETES / FATTY ACID METABOLISM / STRUCTURE-BASED DRUG DESIGN / ALLOSTERIC INHIBITION / POLYKETIDE

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