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Structure paper

TitleInsight Into Steroid Scaffold Formation from the Structure of Human Oxidosqualene Cyclase
Journal, issue, pagesNature, Vol. 432, Page 118-, Year 2004
Publish dateAug 18, 2004 (structure data deposition date)
AuthorsThoma, R. / Schulz-Gasch, T. / D'Arcy, B. / Benz, J. / Aebi, J. / Dehmlow, H. / Hennig, M. / Stihle, M. / Ruf, A.
External linksNature / PubMed:15525992
MethodsX-ray diffraction
Resolution2.1 - 2.2 Å
Structure data

PDB-1w6j:
Structure of human OSC in complex with Ro 48-8071
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-1w6k:
Structure of human OSC in complex with Lanosterol
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-R71:
[4-({6-[ALLYL(METHYL)AMINO]HEXYL}OXY)-2-FLUOROPHENYL](4-BROMOPHENYL)METHANONE

ChemComp-BOG:
octyl beta-D-glucopyranoside / detergent*YM

ChemComp-C14:
TETRADECANE

ChemComp-HOH:
WATER

ChemComp-LAN:
LANOSTEROL

Source
  • homo sapiens (human)
KeywordsISOMERASE / CYCLASE / CHOLESTEROL / LANOSTEROL / MONOTOPIC MEMBRANE PROTEIN / B-OCTYL-GLUCOSIDE / STEROID BIOSYNTHESIS

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