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TitleUnderstanding the role of Leu22 variants in methotrexate resistance: comparison of wild-type and Leu22Arg variant mouse and human dihydrofolate reductase ternary crystal complexes with methotrexate and NADPH.
Journal, issue, pagesActa Crystallogr. ,Sect. D, Vol. 61, Page 147-155, Year 2005
Publish dateAug 2, 2004 (structure data deposition date)
AuthorsCody, V. / Luft, J.R. / Pangborn, W.
External linksActa Crystallogr. ,Sect. D / PubMed:15681865
MethodsX-ray diffraction
Resolution1.9 - 2.5 Å
Structure data

PDB-1u70:
Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22Arg Variant Mouse and Human Dihydrofolate Reductase
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-1u71:
Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22Arg Variant Mouse and Human Dihydrofolate Reductase Ternary Crystal Complexes with Methotrexate and NADPH
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-1u72:
Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22Arg Variant Mouse and Human Dihydrfolate Reductase Ternary Crystal Complexes with Methotrexate and NADPH
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-MTX:
METHOTREXATE

ChemComp-NDP:
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

ChemComp-MXA:
6-(2,5-DIMETHOXY-BENZYL)-5-METHYL-PYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINE

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / variant DHFR mouse / human / human DHFR L22R variant / wild type humand DHFR

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